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Neuromuskuläre Forschung

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Gruppen und Labore

AG Gelpi

Schwerpunkte: Neurodegenerative Erkrankungen inkl. Prionen, Neuropathologie, Epilepsie-Pathologie

Priv.-Doz. Dr. Ellen Gelpi-Mantius, PhD

Kontakt Labor:

Priv.-Doz. Dr. Günther Regelsberger

Kontakt Genetik:

Univ.-Prof. Dr. Thomas Ströbel

Arbeitsschwerpunkte:

  • Unser Schwerpunkt liegt auf der Vertiefung des neuropathologischen Substrats neurodegenerativer Erkrankungen, vor allem die Erfassung früher Gewebsveränderungen auf zellulärer Ebene, Propagation der Pathologie und molekulare Grundlagen der Neurodegeneration; dabei unterstützen wir die Entwicklung von Biomarkern.

  • Methoden: Neuropathologie: Konventionelle histologische Färbungen, Immunhistochemie, Elektronenmikroskopie, Immunfluoreszenz / konfokale Mikroskopie; molekularbiologische einschl. genetische Untersuchungen; Neurochemie: ELISA, RTQuIC.

  • Österreichisches Referenzzentrum zur Erfassung und Dokumentation menschlicher Prionenerkrankungen (ÖRPE): Im Auftrag vom Bundesministerium für Soziales, Gesundheit, Pflege und Konsumentenschutz.

Keywords:

  • neurodegenerative diseases; neuropathology; prion disorders; RTQuIC; tau; synuclein; TDP-43; FUS

AG Koneczny

Schwerpunkte: Myasthenia gravis, Neuroimmunology, IgG4 Autoimmunity

Mag. Inga Koneczny, DPhil

Arbeitsschwerpunkte:

  • Inga Koneczny made groundbreaking contributions to the field of Myasthenia gravis research and IgG4 autoimmunity. During her DPhil studies at the University of Oxford with Prof. Angela Vincent, FRS FRCPath, she was the first to unravel the pathogenic mechanisms of MuSK autoantibodies as a functional block of binding between MuSK and Lrp4, and demonstrated their pathogenicity in vitro. The work was published open-access at PloS One and reached the top 10% of most cited articles in 2017. In her postdoctoral work with Prof. Marc De Baets and Drs Pilar-Martinez-Martinez and Mario Losen, she was the first to discover that MuSK autoantibodies, which belong to the rare IgG4 subclass, are bispecific in vivo in the patient serum, and that bispecific autoantibodies and Fab fragments are pathogenic in vitro. In further projects she investigated the involvement of the thymus in Lrp4 MG, and the impact of long-term immunosuppression on IgG subclass distribution. She also contributed to reviews and wrote a book chapter for the Encyclopedia of Immunobiology. She was awarded three  prestigious stipends from the Austrian science fund and the Austrian academy of sciences, two travel grants, one prize for the best conference poster and was invited speaker at several conferences.

Keywords:

  • myasthenia gravis, neuroimmunology, IgG4 autoimmunity

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